P7C3

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Product Name
P7C3
Size
Catalog #
N-3004-1
Storage
-20°C
Description
P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity1. Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis2. Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease3. Restores hippocampal neurogenesis in a mouse model of Down Syndrome4. The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD5. Active in vivo.
Molecular Mass
474.2
Purity
>98%
Cost (US$)
$60
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Quantity

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1.AA Pieper et al. Cell 2010 142:39
2.T Tesla et al. Proc. Natl. Acad. Sci. USA 2012 109:17016
3.H De Jesus-Cortes et al. Proc. Natl. Acad. Sci. USA 2012 109:17010
4.SE Latchney et al. Neurosci. Lett. 2015 591:86
5.G Wang et al. Cell 2014 158:1324