AK-7

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Product Name
AK-7
Size
Catalog #
N-3003-1
Storage
-20°C
Description
A selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt31. It down-regulates cholesterol biosynthesis genes in primary striatal neurons1. Displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin2.
Molecular Mass
437.4
Purity
>98%
Cost (US$)
$50
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1.DM Taylor et al. ACS Chem. Biol. 2011 6:540
2.V Chopra et al. Cell Rep. 2012 2:1492