Vildagliptin

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Product Name
Vildagliptin
Size
Catalog #
N-2887-1
Storage
-20°C
Description
A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1)1. Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia)2. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model3. Displays protective effects on beta-cells by inhibition of ER stress in a mouse model4. Clinically useful antidiabetic agent.
Molecular Mass
303.4
Purity
>98%
Cost (US$)
$40
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1. B Balas et al. J. Clin. Endocrinol. Metab. 2007 92:1249
2. B Ahren et al. J. Clin. Endocrinol. Metab. 2004 89:2078
3. J Kosaraju et al. J. Pharm. Pharmacol. 2013 65:1773
4. S Shimizu et al. J. Mol. Endocrinol. 2012 49:125