Deoxymannojirimycin HCl

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Product Name
Deoxymannojirimycin HCl
Catalog #
Potent and selective inhibitor of α-mannosidase I1,2. Inhibits the conversion of high mannose to complex oligosaccharides3. Attenuates tunicamycin-, thapsigargin- and Beta Amyloid1-42-induced ER stress dependent neuronal cell death and protects primary cultured mouse cortical neurons from Beta Amyloid 1-42 toxicity4. Increases titers (4 fold) in the production of lentivirus vectors with enhanced efficiency in targeting dendritic cells5,6.
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1. J Bischoff et al. J. Biol. Chem. 1986 261:4766
2. J Bischoff et al. Biochem. Biophys. Res. Commun. 1984 125:324
3. U Fuhrmann et al. Nature 1984 307:755
4. K Miyake and K Nagai Neurotoxicoloy 2009 30:144
5. A Tai et al. J. Biol. Eng. 2011 5:1
6. CL Lee et al. Biotechnol. Bioeng. 2012 109:1551