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A novel proline-containing dipeptide with nootropic and cognition-enhancing over activity1. Rescues alpha-synuclein amyloid toxicity in cellular over models2. Stimulates the expression of NGF and BDNF in rat over hippocampus3. Improves viability of hippocampal HT-22 neurons in a glutamate toxicity over model4. Normalizes blood glucose level and tolerance to glucose load in a streptozotocin diabetic rat model of developing over diabetes5.
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1. RU Ostrovskaya et al. J. Psychopharmacol. 2007 21:611
2. X Jia et al. J. Mol. Biol. 2011 414:699
3. RU Ostrovskaya et al. Bull. Exp. Biol. Med. 2008 146:334
4. TA Antipova et al. Bull. Exp. Biol. Med. 2016 161:58
5. RU Ostrovskaya et al. Bull. Exp. Biol. Med. 2014 156:342