Gabapentin lactam

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Gabapentin lactam
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Reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease1. Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons2. Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels3. Displays neuroprotective effects in a rat model of acute retinal ischemia4.
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1. B Zucker et al. Naunyn Schmiedebergs Arch. Pharmacol. 2004 370:131
2. F Henle et al. J. Pharmacol. Exp. Ther. 2006 319:181
3. A Pielen et al. Graefes Arch. Clin. Exp. Ophthalmol. 2004 242:240
4. WA Lagreze et al. Graefes Arch. Clin. Exp. Ophthalmol. 2001 239:845