Celastrol

ORDER ONLINE  •  CALL 866.753.0747  •  FAX 678.753.0746

Product Name
Celastrol
Size
Catalog #
N-2187-2
Storage
-20°C
Description
Antioxidant and anti-inflammatory agent. Inhibits NFκB (IC50=270 µM)1 It induces heat shock response and cytoprotection in various cells2. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 µM)3. Induces autophagy by targeting AR/miR-101 in prostate cancer cells4. Induces UPR-dependent cell death in cancer cells5. Lowers beta-amyloid levels and reduces pathology in mouse models of Alzheimer’s disease6.
Molecular Mass
450.6
Purity
>98%
Cost (US$)
$240
Place an Order
Quantity

Would you like 10 or more?  Save on cost by requesting a Large Quantity Quote.

1. G Sethi et al. Blood 2007 109:2727
2. SD Westerheide et al. J. Biol. Chem. 2004 279:56053
3. H Yang et al. Cancer Res. 2006 66:4758
4. J Guo et al. PLoS One. 2015 10(10):e0140745
5. AM Fribley et al. Exp. Cell Res. 2015 330:412
6. D Paris et al. J. Neuroinflammation 2010 7:17