Mycophenolate mofetil

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Product Name
Mycophenolate mofetil
Catalog #
A mycophenolic acid prodrug. Immunosuppressive agent useful in prevention of organ allograft rejection1. Is metabolized to mycophenolic acid in vivo which acts by inhibiting the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages2,3. IL-2-dependent T cell proliferation is also inhibited4. Inhibits microglial and astrocytic activation reducing cell death after neuronal injury5. Active in vivo.
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1. AC Allison and EM Eugui Clin. Transplant. 1996 10:77
2. CA Jonsson et al. Cell. Immunol. 2002 216:93
3. AC Allison et al. Ann. NY Acad. Sci. 1993 696:63
4. J Quemeneur et al. J. Immunol. 2002 169:2747
5. F Ebrahimi et al. J. Neuroinflammation 2012 9:89