Mithramycin A

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Product Name
Mithramycin A
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Inhibits DNA methyl transferase1. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression2. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis3. Radiation sensitizer in human tumor models4. Displays neuroprotective effects and improves functional recovery after spinal cord injury in animal models5.
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RK Lin et al. Anticancer Drugs 2007 18:1157
2. Z Jia et al. Cancer Res. 2010 70:1111
3. T-J Lee et al. Mol. Cancer Ther. 2006 5:2737
4. BT Scroggins et al. Int. J. Radiat. Oncol. Biol. Phys. 2017 Oct. 12, Epub
5. JY Lee et al. J. Neurotrauma 2017 Nov. 17, Epub