Candesartan

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Product Name
Candesartan
Size
Catalog #
N-2049-1
Storage
-20°C
Description
Angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively1. Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF or endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis2. Attenuates angiogenesis in hepatocellular carcinoma3. Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease4. Active in vivo and orally active.
Cost (US$)
$30
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1. Y Shibouta et al. J. Pharmacol. Exp. Therap. 1993 266:114
2. SA Bhat et al. Mol. Neurobiol. 2017 Sept 7 Epub
3. F Fan et al. Biomed. Pharmacother. 2016 83:704
4. N Torika et al. CNS Neurosci. Ther. 2018 24:231