FPS-ZM1

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Product Name
FPS-ZM1
Size
Catalog #
N-1635-2
Storage
-20°C
Description
A high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivos1,2. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage3. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling4. Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia5. BBB permeable.
Molecular Mass
327.1
Purity
>98%
Cost (US$)
$138
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1. R Deane et al. J. Clin. Invest. 2012 122:1377
2. Y Hong et al. Neurochem. Res. 2016 41:1192
3. F Yang et al. Stroke 2015 46:1328
4. D Li et al. Neurosci. Lett. 2015 609:109