IU1

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Product Name
IU1
Size
Catalog #
N-1197-1
Storage
4°C
Description
Selective inhibitor of Usp14 (IC50<4 µM). Enhances proteasome activity and substrate proteolysis1,2. Inhibits Dengue virus replication3. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load4. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model5. Cell permeable.
Cost (US$)
$50
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1. BH Lee et al. Nature 2010 467:1179
2. MJ Lee et al. Mol. Cell. Proteomics 2010 10:R110
3. DK Nag and D Finley Virus Res. 2012 165:103
4. C McKinnon et al. Acta Neuropathol. 2016 131:411
5. J-W Min et al. J. Neurochem. 2017 140:826