Phenylbutyrate Na

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Product Name
Phenylbutyrate Na
Catalog #
Chemical chaperone for misfolded proteins1. Resolves ER stress in neuronal cells by aiding protein folding in the ER2. Counteracts impaired glucose homeostasis in a mouse model of type 2 diabetes by preventing islet amyloid formation3. Attenuates atherosclerotic progression and stabilizes existing plaques in mouse model of atherosclerosis via inhibition of ER stress4. Protects against amyloid beta-induced neurotoxicity in a mouse model5. Weak histone deacetylase (HDAC) inhibitor which inhibits glioma cell proliferation6. Active in vivo.
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1. GH Yam et al. Invest. Ophthalmol. Vis. Sci. 2007 48:1683
2. B Kaur et al. Mol. Omics 2018 14:53
3. J Montane et al. FASEB J. 2017 31:5296
4. A Huang et al. Atherosclerosis 2017 266:103
5. E Barbero-Camps et al. Am. J. Pathol. 2014 184:2066
6. IB Appelskog et al. Int. J. Oncol. 2004 24:1419