15N Beta-Amyloid (11-42), U. label
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Recombinant. A DNA sequence encoding the human beta-amyloid (11-42) sequence was expressed in E. coli with N15 as the nitrogen source.
Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). Alzheimer’s diseased brains show significant levels of Abeta (11-40) and Abeta (11-42). The ß-secretase enzyme or ß- amyloid precursor protein-cleaving enzyme (BACE) generates the N terminus of Aß, producing full-length Abeta (1-40 and 1-42) and/or truncated Abeta (11-40 and 11-42). The abundance of Abeta (11-40 and 11-42) produced by BACE suggests that they might be playing an important role in Alzheimer’s disease pathogenesis.
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1) Liu K, et al., (2002) Biochemistry, 41:3128-36.