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(SARS-CoV-2) Papain-like Protease

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Product Name
(SARS-CoV-2) Papain-like Protease
Size
Catalog #
CV-3044-2
(SARS-CoV-2) Papain-like Protease, Recombinant
Storage
-80°C
(Ships on Dry Ice)
Sequence
aa 1-306 (Ser1 - Gln306)
Source
E.coli
Description
SARS-CoV is an enveloped, single and positive-stranded RNA virus. Replication of the genomic RNA of SARS-CoV is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro). The chymotrypsin-like 3CLpro processes the replicase polyprotein at 11 sites, including cleaving itself from the polyprotein to generate a 25-kDa protease product. Papain-like proteases have been shown to process the amino-terminal end of the replicase polyprotein to generate two or three replicase products. Proteolytic processing of the coronavirus replicase polyprotein is essential for generating a functional replication complex. Therefore, the coronavirus replicase-encoded proteases, 3CLpro and PLpro, are potential targets for antiviral drug development.
Molecular Mass
38 kDa (6×His tag at the N-terminus)
Purity
>95%
Cost (US$)
$428
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Quantity

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