We understand these are trying times and we are here to help keep your research moving forward.

As we closely monitor the situation at hand, rPeptide will remain fully operational and continue to practice all safety protocol while taking precautionary measures to ensure there are no interruptions to your research. From our catalog products to our laboratory services, please let us know how we can assist with your research needs.

Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit

ORDER ONLINE  •  CALL 866.753.0747  •  FAX 678.753.0746

Product Name
Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit
Size
1 kit
Catalog #
CV-4002-1
Components:
ACE2 Assay Buffer 25 ml
ACE2 Dilution Buffer 1.5 ml
ACE2 Enzyme 20 µl
ACE2 Substrate 200 µl
ACE2 Inhibitor (0.5 mM) 5 µl
Storage
-20°C
Description
Angiotensin II converting enzyme (ACE2, EC 3.4.17.23), a carboxypeptidase, is part of the renin-angiotensin system (RAS) that controls regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. It also cleaves Angiotensin I to produce Ang 1-9, of unknown function. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of heart and kidney. The inhibitors of ACE2 could be able to regulate hypertension by changing vascular permeability. Screening for small molecule and peptide inhibitors might also help in finding treatment for coronavirus mediated infection. This ACE2 Inhibitor Screening Kit can be used to screen for potent inhibitors of ACE2 activity, it utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. In the presence of an ACE2 specific inhibitor, the enzyme loses its peptidase activity which results in decrease of fluorescence intensity. This assay kit is simple and can be used to identify and characterize ACE2 inhibitors in a high-throughput format.
Cost (US$)
$530
Place an Order
Quantity

Would you like 10 or more?  Save on cost by requesting a Large Quantity Quote.