E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
Recombinant. A DNA sequence encoding the human beta-amyloid (11-42) sequence was expressed in E. Coli.
Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimerâ��s patients, is thought to be the cause of Alzheimerâ��s Disease (AD). Alzheimerâ��s diseased brains show significant levels of Abeta (11-40) and Abeta (11-42). The Ã�-secretase enzyme or Ã�- amyloid precursor protein-cleaving enzyme (BACE) generates the N terminus of AÃ�, producing full-length Abeta (1- 40 and 1-42) and/or truncated Abeta (11-40 and 11-42). The abundance of Abeta (11-40 and 11-42) produced by BACE suggests that they might be playing an important role in Alzheimerâ��s disease pathogenesis.
Place an Order
Would you like 10 or more? Save on cost by requesting a Large Quantity Quote.
1) Liu K, et al., (2002) Biochemistry, 41:3128-36.