Beta-Amyloid (11-40)

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Product Name
Beta-Amyloid (11-40)
Size
1.0 mg
Catalog #
A-1061-2
Storage
-20°C
Sequence
E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
Source
Recombinant. A DNA sequence encoding the human beta-amyloid (11-40) sequence was expressed in E. coli.
Description
Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer�s patients, is thought to be the cause of Alzheimer�s Disease (AD). Alzheimer�s diseased brains show significant levels of Abeta (11-40) and Abeta (11-42). The ��-secretase enzyme or ��- amyloid precursor protein-cleaving enzyme (BACE) generates the N terminus of A��, producing full-length Abeta (1-40 and 1-42) and/or truncated Abeta (11-40 and 11-42). The abundance of Abeta (11-40 and 11-42) produced by BACE suggests that they might be playing an important role in Alzheimer�s disease pathogenesis.
Molecular Mass
3151.7 Da
Purity
>97%
Cost (US$)
1) Liu K, et al., (2002) Biochemistry, 41:3128-36.