E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
Recombinant. A DNA sequence encoding the human beta-amyloid (11-40) sequence was expressed in E. coli.
Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of AlzheimerÃ¢ï¿½ï¿½s patients, is thought to be the cause of AlzheimerÃ¢ï¿½ï¿½s Disease (AD). AlzheimerÃ¢ï¿½ï¿½s diseased brains show significant levels of Abeta (11-40) and Abeta (11-42). The Ã�ï¿½-secretase enzyme or Ã�ï¿½- amyloid precursor protein-cleaving enzyme (BACE) generates the N terminus of AÃ�ï¿½, producing full-length Abeta (1-40 and 1-42) and/or truncated Abeta (11-40 and 11-42). The abundance of Abeta (11-40 and 11-42) produced by BACE suggests that they might be playing an important role in AlzheimerÃ¢ï¿½ï¿½s disease pathogenesis.
1) Liu K, et al., (2002) Biochemistry, 41:3128-36.