PKC-412 (Midostaurin)

Pan-specific kinase inhibitor. Selectively induces G1 arrest and apoptosis in Ba/F3 cells expressing mutant FLT3, IC50<10 nM. FLT3 ligand impedes the efficacy of inhibition by PKC-412. Potential therapeutic use in pancreatic cancer. Cell permeable. Active in vivo.

Catalog ID: CV-1004-1

$95.00

  • Product Details

    • Size: 1.0 mg
    • Physical State: White powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 570.6
  • References

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    4. El Fitori, J., et al., (2007) Cancer, 110 : 1457