Nafamostat Mesylate

A potent and reversible serine protease inhibitor (IC50=0.3-54 uM). Selectively inhibits human tryptase (Ki = 95.3 pM) when employed at low concentrations. Dramatically suppresses pulmonary dysfunction in a rat model and inhibits airway eosinophilic inflammation. Anticoagulant, thrombin inhibitor which attenuates neuronal damage in a transient focal cerebral ischemia model. Also blocks TRPM7 in the absence of extracellular divalent cations. Cell permeable.

Catalog ID: CV-1002-2

$270.00

  • Product Details

    • Size: 50 mg
    • Physical State: White powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 539.6
  • References

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    4. Ishizaki, M., et al., (2008) J. Pharmacol. Sci., 108 : 355
    5. Chen, T., et al., (2014) Sci. Rep., 4 : 5531
    6. Chen, X., et al., (2010) Mol. Brain, 3 : 38