Beta-Amyloid (1-42), Scrambled

Name: Beta-Amyloid (1-42), Scrambled
SKU: A-1004-2
Price: 350.00 USD
Availability: InStock

Beta-amyloid (A-beta) has been long reported as the major constituent of amyloid plaques in the brains of Alzheimer’s patients, and is believed by many to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease and afflicts more than 10% of the population over 65. Recombinantly expressed and sourced from E. coli, rPeptide’s high quality beta-amyloid products offer batch-to-batch consistency and ultrapure starting material for your research needs. The TFA (trifluoro-acetic acid) counter-ion is a peptide which was lyophilized in a final solution containing TFA and is a popular choice for researchers wishing to build on previous studies using this same product. Scrambled peptide is a control peptide which does not aggregate as native beta-amyloid. It is used as a negative control for aggregation.

Catalog ID: A-1004-2

$350.00

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Product Details
- Size: 1.0 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
  K V K G L I D G A H I G D L V Y E F M D S N S A I F R E G V G A G H V H V A Q V E F
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) scrambled sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
References

1. Yankner, B,A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943
5. Hu, J., et al., (1998) Brain Research, 785 : 195-206
Publications

A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation.
Alzheimer's & Dementia; doi: 10.1002/trc2.12029.
Caneus,J., Akanda, N., Rumsey,J.,Guo, X., Jackson, M., Long, C., Sommerhage, F., Georgieva, S., Kanaan, N., Morgan, D., Hickman, J.

Effects of a Nutritional Supplement on Cognitive Function in Aged Dogs and on Synaptic Function of Primary Cultured Neurons
Animals (Basel).; doi: 10.3390/ani9070393.
Maria Elena Pero, Laura Cortese, Vincenzo Mastellone, Raffaella Tudisco, Nadia Musco, Anna Scandurra, Biagio D’Aniello, Giuseppe Vassalotti, Francesca Bartolini, Pietro Lombardi

Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells.
Neurosci. Bull.; doi: 10.1007/s12264-016-0034-9..
Dema Najem, Michelle Bamji-Mirza, Ze Yang, Wandong Zhang

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.
link.springer.com; https://doi.org/10.1007/s12035-017-0646-8.
Wencel, P.L., Lukiw, W.J., Strosznajder, J.B., Strosznajder, R.P

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer’s disease
Wiley Online Library; |https://doi.org/10.15252/emmm.201708300.
Sophie Steeland , Nina Gorlé , Charysse Vandendriessche , Sriram Balusu , Marjana Brkic , Caroline Van Cauwenberghe , Griet Van Imschoot , Elien Van Wonterghem , Riet De Rycke , Anneke Kremer , Saskia Lippens , Edward Stopa , Conrad E Johanson , Claude Libert , Roosmarijn E Vandenbroucke

Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders.
Science Direct; https://doi.org/10.1016/j.bbamcr.2017.11.003.
Czapski,G.A., Cieślik,M., Wencel,P.L., Wójtowicz,S., Strosznajder,R.P., Strosznajder, J.B.

Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer.
BioMed Central; 10.1186/s13195-017-0257-7.
Doris Lambracht-Washington Min Fu, Pat Frost and Roger N. Rosenberg

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1–42-mediated cytotoxicity.
FEBS Open Bio; doi: 10.1002/2211-5463.12156.
Cameron, RT.; Whiteley, E.; Day, JP.; Parachikova, AI.; Baillie, GS.

Immunization with Small Amyloid-β-derived Cyclopeptide Conjugates Diminishes Amyloid-β-Induced Neurodegeneration in Mice.
Journal of Alzheimer's Disease; doi: 10.3233/JAD-151136.
Mulder Cornelis K, Dong Yuna, Brugghe Humphrey F, Timmermans Hans A.M, Tilstra, Wichard, Westdijk Janny, van Riet Elly, van Steeg Harry, Hoogerhout Peter, Eisel Ulrich L.M.

Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta
BioMed Central; DOI: 10.1186/s12974-016-0484-z.
Ryan C. McCarthy, Dah-Yuu Lu, Ahmed Alkhateeb, Andrew M. Gardeck, Chih-Hao Lee, and Marianne Wessling-Resnick

Hippocampal Injections of Oligomeric Amyloid β-peptide (1–42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway.
Front Aging Neurosci.; doi: 10.3389/fnagi.2015.00245..
Pierre Faucher, Nicole Mons, Jacques Micheau, Caroline Louis, Daniel J. Beracochea

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins.
PLOS One; DOI: 10.1371/journal.pone.0137193.
Magdalena Cieślik, Grzegorz A. Czapski, Joanna B. Strosznajder

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer’s disease
Wiley Online Library; DOI: 10.1111/acel.12281.
Silvia Maioli, Maria Lodeiro, Paula Merino-Serrais, Farshad Falahati, Wasim Khan, Elena Puerta, Alina Codita, Roberto Rimondini, Maria J. Ramirez, Andrew Simmons, Francisco Gil-Bea, Eric Westman, Angel Cedazo-Minguez1, and for the Alzheimer's Disease Neuroimaging Initiative

Reciprocal modulation of Aβ42 aggregation by copper and homocysteine.
Front Aging Neurosci.; https://doi.org/10.3389/fnagi.2014.00237.
Salla Keskitalo, Melinda Farkas, Michael Hanenberg, Anita Szodorai, Luka Kulic, Alexander Semmler, Michael Weller, Roger M. Nitsch, Michael Linnebank

The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death
Science Direct; http://dx.doi.org/10.1016/j.mcn.2014.05.002.
Ryan T. Camerona, Steven D. Quinnb, Lynn S. Cairnsa, Ruth MacLeoda, Ifor D.W. Samuelb, Brian O. Smitha, J. Carlos Penedob, George S. Baillie

Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson’s Disease Patients and Controls
PLOS One; DOI: 10.1371/journal.pone.0088604.
Walter Maetzler, Anja Apel, Markus Langkamp, Christian Deuschle, Sarah Selina Dilger, Johannes Georg Stirnkorb, Claudia Schulte, Erwin Schleicher, Thomas Gasser, Daniela Berg

Beta-Amyloid (1-42), Scrambled

Product Details

References

Publications