Beta-Amyloid (1-42), Scrambled
Beta-amyloid (A-beta) has been long reported as the major constituent of amyloid plaques in the brains of Alzheimer’s patients, and is believed by many to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease and afflicts more than 10% of the population over 65. Recombinantly expressed and sourced from E. coli, rPeptide’s high quality beta-amyloid products offer batch-to-batch consistency and ultrapure starting material for your research needs. The TFA (trifluoro-acetic acid) counter-ion is a peptide which was lyophilized in a final solution containing TFA and is a popular choice for researchers wishing to build on previous studies using this same product. Scrambled peptide is a control peptide which does not aggregate as native beta-amyloid. It is used as a negative control for aggregation.
- Size: 1.0 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:K V K G L I D G A H I G D L V Y E F M D S N S A I F R E G V G A G H V H V A Q V E F
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) scrambled sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
References1. Yankner, B,A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943
5. Hu, J., et al., (1998) Brain Research, 785 : 195-206
PublicationsAlzheimer's & Dementia; doi: 10.1002/trc2.12029.Animals (Basel).; doi: 10.3390/ani9070393.Neurosci. Bull.; doi: 10.1007/s12264-016-0034-9..link.springer.com; https://doi.org/10.1007/s12035-017-0646-8.Wiley Online Library; |https://doi.org/10.15252/emmm.201708300.Science Direct; https://doi.org/10.1016/j.bbamcr.2017.11.003.FEBS Open Bio; doi: 10.1002/2211-5463.12156.Journal of Alzheimer's Disease; doi: 10.3233/JAD-151136.BioMed Central; DOI: 10.1186/s12974-016-0484-z.Front Aging Neurosci.; doi: 10.3389/fnagi.2015.00245..PLOS One; DOI: 10.1371/journal.pone.0137193.Wiley Online Library; DOI: 10.1111/acel.12281.Front Aging Neurosci.; https://doi.org/10.3389/fnagi.2014.00237.Science Direct; http://dx.doi.org/10.1016/j.mcn.2014.05.002.PLOS One; DOI: 10.1371/journal.pone.0088604.