Beta-Amyloid (1-42), Mouse, Rat

Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).

About the product: Expressed recombinantly in E. coli, the mouse/rat Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.

Applications: The Beta-Amyloid (1-42), mouse/rat peptide is supplied in the NH4OH counter ion ensuring a highly monomeric stating material that could be suited to aggregation studies, seeding experiments, molecular standards and more.

Catalog ID: A-1008-2

$495.00

  • Product Details

    • Size: 1.0 mg
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      D A E F G H D S G F E V R H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
    • Source: Recombinant. A DNA sequence encoding the mouse/rat beta-amyloid(1-42) sequence was expressed in E. coli
    • Purity: >97% by Mass Spec.
    • Molecular Mass: 4,417Da theoretical
  • References

    1. Yankner, B., et al., (1990) Science, 250 : 279-282
    2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
    3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
    4. Gericke, C., et al., (2020) Front. Immunol., 11 : 1029

  • Publications

    Misfolded amyloid β-42 induced impairment of the endosomal-lysosomal pathway revealed by real-time optical monitoring

    bioRxiv; https://doi.org/10.1101/598540.

    Karen E Marshall, Devkee Vadukul, Kevin Staras, Louise C Serpell