Beta-Amyloid (1-40), Y10W Mutant
Product background: Beta-amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, beta-amyloid (1-40) with the Y10W mutation is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The TFA (trifluoroacetic acid) counter ion ensues a highly monomeric stating material that could be suited to aggregation studies, seeding experiments, molecular standards and more.
$475.00
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Product Details
- Size: 1.0 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G W E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-40) sequence, with a point mutation (Y10W), was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,353 Da theoretical
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References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943
