Description:
Lyophilized powder. Purity > 95% by SDS-PAGE and Mass Spec; Alpha-Synuclein is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. Alpha-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. Alpha-Synuclein appears to associate with other proteins that aggregate and is found in amyloid plaques and neuritic tangles in Alzheimer’s disease.

References:
Jakes, R. et al. 1994, FEBS Letters, 345 , 27
Masliah, E. et. al., 2001. Proc. Natl. Acad. Sci., USA, 98, 12245
Ueda, K., et. al. 1993. Proc. Natl. Acad. Sci., USA, 90, 11282

Data Sheet (Adobe PDF)

Catalog No: S-1001-1 Quantity: 0.5 mg Price: $300

Catalog No: S-1001-2 Quantity: 1.0 mg Price: $500