H-Val-Met-Leu-Lys-Lys-Lys-Gln-Tyr-Thr-Ser-Ile-His-His-Gly-Val-Val-Glu-Val-Asp-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH; APP 721-770

Description:
Lyophilized solid; TFA salt; Purity > 95% packed under inert gas; hygroscopic; light sensitive. A 50-amino acid peptide, results from the γ-secretase cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Leu720-Val721. May also serve as one of the precursors for the generation of the toxic C31 fragment of APP (Cat. No. A-1201)

References:
Gu, Y., et al. 2001. J. Biol. Chem. 276, 35235
Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481
Lu, D.C., et al. 2000. Nat. Med. 6, 397

Data Sheet (Adobe PDF)

Catalog No: A-1202-1 Quantity: 250 ug Price: $180