Description:
Lyophilized powder. Purity > 95% by SDS-PAGE; A deletion mutant of Alpha-synuclein (amino acids 61-140). Additional amino acid (Met) is attached at the N-terminus. Alpha-Synuclein is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. Alpha-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. Alpha-Synuclein appears to associate with other proteins that aggregate and is found in amyloid plaques and neuritic tangles in Alzheimer’s disease.

References:
Park, S. M. et al. (2002) Blood, 100(7) 2506
Park, S. M. et al. (2002) Biochemisty. 41, 4137
Conway, K.A. et. al., (2000) Biochemistry, 39: 2552
Jakes, R. et al. 1994, FEBS Letters, 345, 27
Masliah, E. et. al., 2001. Proc. Natl. Acad. Sci., USA, 98, 12245
Ueda, K., et. al. 1993. Proc. Natl. Acad. Sci., USA, 90, 11282

Data Sheet (Adobe PDF)

Catalog No: S-1013-1 Quantity: 0.5 mg Price: $300